Current Issue : January-March Volume : 2021 Issue Number : 1 Articles : 3 Articles
The objective of this study was to formulate and evaluate buccal patches containing hydrochlorothiazide (HCZ) and perindopril for sustained release. Films were fabricated by solvent casting using combinations of mucoadhesive polymers such as hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose (HPC), polyvinyl alcohol (PVA), polyvinyl pyrolidone (PVP) and ethyl cellulose (EC) as a backing layer. The patches were evaluated for physicochemical characteristics such as weight, thickness, surface pH, folding endurance, bioadhesive strength, swelling index, drug content, tensile strength, elongation at break and mucoadhesive time and ex-vivo permeation studies. The FT-IR spectral studies showed no interaction between drug and polymer. Physicochemical characteristics of all the formulations were satisfactory. The stability studies did not show any significant difference in external appearance, drug content, swelling index and ex-vivo drug permeation after a storage period of 2 months....
The objective of the present study was to prepare the floating tablets of opioid-receptor agonist loperamide. Floating tablets constitute an innovative dosage form that overcome the problems of large frequency of dosing and provides a sustained action for a longer period of time. In the view of enhancing bioavailability an attempt has been made to prepare floating tablets and to know the effect of different grades of polymers and also different types of polymers on formulations. Floating tablets were prepared by direct compression method using different polymers like HPMC K4M, HPMC K15M HPMC K100M. The prepared tablets were evaluated for pre-compression and post compression parameters. All the formulations showed low weight variation with sustained release of drug. The physical properties like hardness, friability and drug content of all the formulations were within the acceptable limits. The selected F9 formulations were subjected to stability studies at 40±2°C or 75±5% RH for 30 days....
Non-invasive transdermal drug delivery (NTDD) system in a novel method of drug delivery. This review article describes the various delivery considerations and extraneous factors in developing a strategy to pursue an alternate route of administration for systemic delivery. This system is a technique that provides drug absorption via the skin. The system has many advantages over conventional administration routes such as intravenous or oral administration for systemic and local drug delivery with simple administration. Liposomes are the vesicles that can encapsulate a drug that is unfavorable for transdermal delivery. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake and improving biodistribution of compounds to target sites in-vivo. This enables effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity. However, horny layer of stratum corneum (SC) is the main barrier for efficient transdermal delivery of liposomes. Iontophoresis when used with weak electric current improves the transdermal delivery of liposomes by enhancing their ability to penetrate through the skin. In this review, we provide an overview of considerations for WEC when used for transdermal drug delivery. We discuss a novel perspective on the mechanism of WEC-mediated transdermal delivery of liposomes and lastly the applications of liposomes in transdermal drug delivery system....
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